Tackle positioning

A friend* has returned to road cycling after a couple of years of mostly MTB riding and can't seem to find a comfy saddle position. MTB riding was always in baggies without a liner whereas he's wearing bibs for road riding. Road rides are no more than two hours (anything from around 10 - 30 miles). He's noticed a small perineal lump (pea sized) on the right hand side (dominant leg side) that's under the skin. No soresness, heat, or redness on the skin itself so he's guessing it's probably a cyst, although it is quite hard and painful when palpated. Saddle pain is apparent from this area typically after the first hour of riding.

Experiments continuing with saddle fore/aft, angle, and different bibs. Also considering trying a different saddle design. Current saddle is quite long-nosed and narrow but with good padding and is generally comfortable until the issue arises. Narrow nose suits him due to sprinter proportion thighs.

Considering using a short nose saddle but the question arose about how those feel in relation to where the testicles sit (cue images of Buster Gonad). And, more generally, about positioning on a conventional saddle. Obviously everyone is different in terms of body position/pelvis rotation/knackers size but should testicles be coming into contact with the nose of a conventional saddle, or should they be, um, hanging over the nose? And when wearing bibs is the side you dress a factor?