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Professor Yannis Pitsiladis says his methods detect drugs in body for longer

A scientist at the University of Brighton has outlined how he believes the research he is undertaking will help snare drug cheats whose use of performance enhancing substances goes undetected by current anti-doping testing – and says his methods would have caught Lance Armstrong.

Professor Yannis Pitsiladis’s research is focused on detecting fluctuations in Ribonucleic acid (RNA), which together with DNA and proteins are essential to all known forms of life.

He says the signature that the use of drugs leaves in RNA can be detected months, perhaps years, after an athlete has doped – greatly increasing the window in which traces can be found.

He told the Argus: “At present testers can detect a droplet in the size of an Olympic swimming pool. But the problem is most drugs leave the system in 48 hours.

“So although the tests are incredibly sophisticated, the drugs have already left the body so there is no trace. But I can detect the drug after it has left the system and that is how we will catch the cheats.

“There is no point looking for the drugs, we need to look at what is left behind,” added the academic, who sits on the International Olympic Committee’s Medical and Scientific Commission and is also a member of the Executive Committee and Chair of the Scientific Commission of the International Sports Medicine Federation.

Professor Pitsiladis’s interest in anti-doping was sparked in 2006 when he was undertaking research into what made the world’s top athletes so successful, and was told by journalists that the sportspeople he was studying were winning with the help of drugs.

He took the allegations to the International Association of Athletics Federations (IAAF) – an organisation whose president, Lord Coe, is now dealing with the fallout from the doping scandal centred on Russian athletes in particular that broke last year.

 “I looked at my findings and was asked if they were doping or not. I couldn’t tell and I soon realised the tests and technology I was using to tell why people were so great were the same used to see if athletes are doping,” said the scientist.

During the past decade, his research has been concentrated on finding ways to detect athletes who are cheating, including the World Anti-Doping Agency funding his work at the University of Glasgow before he moved to Sussex.

He discovered that traces of doping were left in the body’s RNA through a study that saw him take blood samples from runners, who then took EPO, finding traces of it there several weeks afterwards.

“It is like a dimmer switch,” he explained. “When the EPO is taken the body reacts by turning up or down the RNA sequences. It was a very important finding and very exciting.”

It’s been two years since we reported on his WADA-funded research in Glasgow, and the scientist is calling for funding so he can continue his research, as well as greater co-operation between those studying how to fight doping.

> 'Perfect' EPO blood-doping detection system in the pipeline?

He said: “There’s simply not enough funding for anti-doping and because there is no funding the top scientists are not attracted to it.

“At the moment in this country there is just me looking into this. That needs to change and there has to be support.

“But I’m confident with the funding we can eradicate doping and change sport forever.”

“It is very frustrating because the technology is there, the science is there but the research needs to be done and that costs money.

“There is very little money around and there are fewer and fewer scientists carrying out the work because there is no money.

“I think outside companies such as from the biotech world can be part of this. They already have the technology and with their help we could solve the problem. It could be a very special project to be part of.”

“The other thing I have stressed is the need for consortia,” added Professor Pitsiladis. “I don’t just want my lab to get funding, we all need to work together and share results. At the moment there are too few scientists working on separate projects.”

Born in Scotland, Simon moved to London aged seven and now lives in the Oxfordshire Cotswolds with his miniature schnauzer, Elodie. He fell in love with cycling one Saturday morning in 1994 while living in Italy when Milan-San Remo went past his front door. A daily cycle commuter in London back before riding to work started to boom, he's been news editor at road.cc since 2009. Handily for work, he speaks French and Italian. He doesn't get to ride his Colnago as often as he'd like, and freely admits he's much more adept at cooking than fettling with bikes.

5 comments

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danthomascyclist [329 posts] 1 year ago
4 likes
Quote:

He says the signature that the use of drugs leaves in RNA can be detected months, perhaps years, after an athlete has doped

If his testing is validated and implemented I'll stock-up on popcorn for the ensuing drama

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Leviathan [2558 posts] 1 year ago
1 like

If, if, he can do this it also proves that doping provides lifelong performance improvements and life bans are back on the cards. But what if you took steroids or any other banned drug for geniune medical purposes? Minefield.

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barbarus [434 posts] 1 year ago
4 likes

I'm not sure whether he's saying that doping offers long lasting performance benefits; only that it leaves a long lasting trace. Definitely interesting!

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jollygoodvelo [1616 posts] 1 year ago
2 likes

Firstly and most importantly - if this new line of research leads to cleaner sport I am completely in favour and wish him every success.

 

But hold on - "in 2006, Professor Yannis Pitsiladis was studying some of the world’s greatest athletes to discover what it was that made them so special.  [...] during his research he was approached by journalists who told him his athletes were cheats."  I might query which rock he'd been living under to not realise - in 2006! - that there is doping in sport.  In 2006 there were adults walking around born since Ben Johnson's Olympic 100m of 1988.  

 

And finally: at no point is he directly quoted as saying "I'd have caught Armstrong."  It's a reasonable claim for him to make but if he actually said it, why is he not quoted?  I also might quibble that Armstrong retired at the end of 2005 and didn't return until 2009, so I suspect that's a link made by the Argus article - purely to get traffic...

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Paul J [928 posts] 1 year ago
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The major work of the WADA funded study in Glasgow on cyclists a few years ago was carried out by Yannis' former student Jerome Durussel, aided greatly by Martin Mooses.